Editorial image for Defend, Hard-training health support.
Development Template

Built as a development file, not a finished launch.

Defend is written carefully because the category needs discipline. It supports hard-training health across defined axes without pretending to be medical care.

N°05 WRAITH

Defend

Hard-training health support.

  • Vitamin D3 4
  • Quercetin Phytosome 500 mg
  • Vitamin C 1
Dose
8 capsules plus 2 softgels at the 200 lb reference dose
In Development
What It Is For
  • Daily use

    Defend is a pack architecture for hard-training health support, not an acute-feel product.

  • Repeated use

    Relevant markers are bloodwork, diet, training load, and consistency, not day-one sensation.

Ingredient / Dose Table
Active Dose Form
Vitamin D3 4,000 IU at reference dose Cholecalciferol in softgel
Quercetin Phytosome 500 mg Quercefit by Indena
Vitamin C 1,000 mg Ascorbic acid
Zinc 25 mg elemental Zinc bisglycinate, TRAACS preferred
TUDCA 500 mg Tauroursodeoxycholic acid
Silymarin 420 mg silymarin equivalent Siliphos, silybin-phytosome
Berberine HCl 1,000 mg 97 percent or greater, Berberis aristata
Omega-3 2,000 mg, providing 1,400 mg EPA and 600 mg DHA EPA-rich triglyceride form softgel
Why We Built It This Way

Research Summary

Hard training creates a broader health-support problem than a multivitamin can solve. Defend uses a pack architecture because the relevant clinical doses do not fit into a minimalist capsule count.

Mechanism Map

  • Hepatic axis: TUDCA and silymarin support bile-flow and hepatocyte antioxidant pathways.
  • Metabolic axis: berberine supports healthy lipid and glucose metabolism already within normal range.
  • Immune axis: vitamin D3, vitamin C, zinc, and quercetin phytosome support immune function during hard training.
  • Cardiovascular axis: EPA-rich omega-3 supports triglyceride and cardiovascular health parameters.
  • Oxidative axis: vitamin C, silymarin, quercetin, and omega-3 address different parts of oxidative load without pretending to erase training stress.

Dosing Architecture

Defend uses a weight-tiered protocol as a pragmatic pack architecture, not because every ingredient has strict mg/kg evidence. The reference serving anchors the strongest clinical-dose logic.

Form Rationale

Several ingredients require specific forms to make the formula defensible: Quercefit, Siliphos, berberine HCl, zinc bisglycinate, cholecalciferol, and triglyceride-form EPA-rich omega-3.

What This Does Not Do

  • Not designed or marketed for drug-exposure mitigation, nor to diagnose, treat, cure, or prevent liver, cardiovascular, lipid, or glucose disorders. Users with diagnosed conditions should speak with a clinician.
  • Not a multivitamin.
  • Not a substitute for bloodwork, medical care, sleep, diet, or training management.
What We Excluded and Why
  • Chromium

    Excluded because berberine covers the glucose-metabolism territory with a stronger evidence base.

  • Cinnamon

    Excluded because effect sizes are inconsistent and cassia coumarin content conflicts with the hepatic-support architecture.

  • Digestive enzymes

    Rejected as non-essential label padding without meaningful outcome evidence in healthy hard-training adults.

  • ALA

    Excluded as redundant with silymarin and berberine on the glucose and oxidative axes, with poorer stability economics.

  • Hormonal support ingredients

    Tongkat Ali, boron, and ashwagandha are excluded to preserve Restore and Edge territory.

Evidence Limitations
  • Many cited studies are in clinical or risk-enriched populations; customer-facing claims remain general structure/function claims.
  • Supplements are not a substitute for clinical care for established cardiovascular conditions, hematocrit abnormalities, arrhythmia concerns, or organ injury.
  • The exact multi-ingredient pack has not been tested as a single formula.
Supplement Facts
Pending

Supplement Facts will be added before this product ships.

Directions
Serving Size
8 capsules plus 2 softgels at the 200 lb reference dose
Dosing Protocol
151 to 180 lb uses 7 capsules, 4,000 IU D3, and 875 mg berberine. 181 to 210 lb uses 8 capsules, 4,000 IU D3, and 1,000 mg berberine. 211 lb and above uses 8 capsules, 5,000 IU D3, and 1,000 mg berberine.
Timing
With the largest fat-containing meal.
Third-Party Testing

Production batches are third-party tested before shipment where applicable. Identity, potency, heavy metals, microbiology, and sports nutrition adulterant panels are published when available.

View lot-level testing records

FAQ

Is Defend a medical product?

No. Defend is a hard-training health support pack and is not designed, labeled, or marketed for drug exposure or medical use.

Why so many capsules?

The clinical doses do not fit a minimalist capsule count. Lowering the count would mean lowering the standard.

References
  1. [1] Bergman P et al. Vitamin D and respiratory tract infections: systematic review and meta-analysis of randomized controlled trials. PLoS One. 2013. PMID: 23242238.
  2. [2] Riva A et al. Improved oral absorption of quercetin from Quercefit. Journal of Dietary Supplements. 2019. PMID: 30328046.
  3. [3] Rondanelli M et al. Quercetin phytosome and immune function evidence cited in Defend audit. Life. 2022. DOI: 10.3390/life12010066.
  4. [4] Di Pierro F et al. Quercetin phytosome clinical evidence cited in Defend audit. 2021. PMID: 34135619.
  5. [5] Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews.
  6. [6] Science M et al. Zinc for the treatment of the common cold: systematic review and meta-analysis. CMAJ. 2012. PMID: 22566526.
  7. [7] Cochrane Review. Zinc for prevention and treatment of the common cold. CD014914. 2024.
  8. [8] Crosignani A et al. Tauroursodeoxycholic acid for chronic cholestatic liver disease: dose-response RCT. Dig Dis Sci. 1996. PMID: 8674405.
  9. [9] Ma X et al. TUDCA versus UDCA in primary biliary cholangitis: multicenter randomized trial. Medicine. 2016.
  10. [10] Wei J et al. Silymarin in NAFLD/NASH: meta-analysis of randomized controlled trials. Ann Hepatol. 2024. PMID: 38579127.
  11. [11] Kim et al. Silymarin effects on liver enzymes: systematic review and meta-analysis. 2024. PMC10946183.
  12. [12] Blais P et al. Berberine and lipid profile: systematic review and meta-analysis. 2023. PMID: 37183391.
  13. [13] Lan J et al. Meta-analysis of berberine in treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015.
  14. [14] Yin J et al. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008.
  15. [15] Wang et al. Dose-response relationship between omega-3 fatty acids and triglycerides. J Am Heart Assoc. 2024. DOI: 10.1161/JAHA.123.029512.
  16. [16] Khan SU et al. Effect of omega-3 fatty acids on cardiovascular outcomes: systematic review and meta-analysis. eClinicalMedicine. 2021. PMC8413259.
California Prop 65
WARNING:

Consuming this product can expose you to chemicals including lead and cadmium, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Reviews

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